What is Sildenafil's Mechanism of Action?


When sexual stimulation occurs, nitric oxide (NO), a naturally occurring molecule in the body, is released into the corpora cavernosa of the penis. The two spongy masses of tissue that run the length of the penis are known as the corpora cavernosa. Following that, NO causes the release of

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When sexual stimulation occurs, nitric oxide (NO), a naturally occurring molecule in the body, is released into the corpora cavernosa of the penis. The two spongy masses of tissue that run the length of the penis are known as the corpora cavernosa. Following that, NO causes the release of a particular enzyme that raises the level of cyclic guanosine monophosphate (cGMP).

The chemical messenger cGMP induces blood vessels in the penis to relax and enlarge, which is helpful for erectile function. When sexual stimulation occurs, this permits blood to flow freely into the penis, resulting in a hard and long-lasting erection.
Sildenafil citrate increases the impact of NO by inhibiting phosphodiesterase type 5 enzyme (PDE5). PDE5 is responsible for a decrease in cGMP, which is bad for erections because it causes them to fade. By suppressing PDE5, these efficient ED medications assist men in obtaining an erection.

What is the best way to take Sildenafil?

Take sildenafil tablets 30-60 minutes before you want to start sexual activity for the greatest benefits. This medication should be consumed whole with a glass of water, and it lasts for 4 to 6 hours in the body. As a result, there is no need to rush in order to get in the mood for sex.

This drug should not be taken with a heavy meal or a high-fat meal. This can slow down absorption and delay the start of side effects. Also, avoid or limit alcohol consumption because it can impair the medication's effectiveness. During treatment, keep the following helpful hints in mind:

  • On its own, this drug does not cause an erection.
  • These medications can only help men get an erection if they are sexually stimulated.
  • If a 50 mg dose does not work, you may wish to try a 100 mg dose of sildenafil.

It may not work the first time for some individuals, but specialists normally advocate trying this medicine four to six times before moving on to another treatment option.

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How long does it take for Sildenafil to work?

Apart from what is sildenafil, a typical query is how long does it take for it to start working. The biggest effects are usually felt within 30 minutes to 2.5 hours after ingestion. Some guys claim to have had an erection in as little as 12 minutes, and these men are known as 'first responders.' Most males, on the other hand, begin to feel the affects after 27 minutes. As a result, the outcomes differ from one person to the next.

A clinical trial was conducted to determine the onset of sildenafil's efficacy in the treatment of erectile dysfunction. To compare the effects, 17 participants in the trial were given either 50 mg of this erectile dysfunction therapy or inert placebo pills. The results were determined using a device that assesses the quality of erections, which was followed by visual sexual stimulation. The following were the results:

  • The average time it took for erections to appear was 27 minutes.
  • Within 30 minutes, 71% of the guys had erections.
  •  Within 45 minutes, 82 percent of the guys had reacted.

These erectile dysfunction tablets have been shown in clinical research to help men get an erection that is suitable for sexual engagement in the majority of patients. The recommended initial dose of sildenafil is 50 mg, although most men raise it to 100 mg.

When You Take Too Much Sildenafil, What Happens?

In general, this drug is thought to be a safe treatment that has been used by numerous men over the world with no serious side effects. Viagra pills have been shown in clinical research to help men get an erection, regardless of whether their erection problems are caused by physical or psychological issues. Some men, however, question if increasing the dose may result in even better results.

Although some men benefit from a larger dose, most patients should avoid doing so because it raises their risk of sildenafil side effects. A reduction in blood pressure is one of the side effects linked with larger doses. Unwanted side effects include weakness, dizziness, and nausea. Rapid breathing, blurred vision, and difficulty concentrating are some of the other side effects of large doses.
Priapism is another danger connected with high erectile dysfunction medication doses. An erection that lasts more than 4 hours is indicative of this disorder. It is normally not induced by sexual excitement, but it can occur if there is an excessive amount of blood flow into the penis. Priapism is a rare side effect that can occur as a result of taking too much erectile dysfunction medication. This side effect can be avoided by carefully following the usage and dosage guidelines.

Is Sildenafil a Good Alternative to Viagra?
Sildenafil is the generic version of Viagra, so it's also known as generic Viagra. Erectile dysfunction is commonly treated with both generic Viagra and its brand-name counterpart. The active components in these drugs are the same, yet they are manufactured by different pharmaceutical companies. The generic and branded versions of Viagra are identical in the following ways:

  • The strength or dosages of the drugs
  • Efficacy, or how well they function in the body
  • Their side effect profiles and safety profiles are identical.
  • How long does it take for them to start working?
  • The effects of both erectile dysfunction medications last the same amount of time.

When the patent on Viagra expired, firms other than the original manufacturer were granted rights to manufacture the drug. They have the same chemical formula and must show regulatory authorities that they are bioequivalent. This means the generic medication must have the same pharmacological qualities and work in the same way in the body.

The most significant distinction is that generic sildenafil citrate is far less expensive than Viagra. When compared to the typical costs of the brand medication, you can anticipate to pay as little as 10% to 20% less for generic Viagra. Because the generic business is governed by regulations that do not force them to redo costly clinical studies, generic companies are allowed to sell their products at lower prices.

Simply go on to our erectile med generic website to get the best erectile dysfunction medicine. We offer quick online access to low-cost drugs with the added benefit of home delivery. Secure Sockets Layer (SSL) software, which reliably encrypts information, is used to keep all transactions secure. By effectively treating ED, you can reclaim a pleasant sex life by purchasing sildenafil today.

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